Anti-XRCC6 Rabbit Polyclonal Antibody HRP Horseradish
Comparison of DNA repair protein expression and activities
Concomitantly, DNA-bound Ku70/80 proteins serve as a docking platform for sequential binding of C-NHEJ components and for an array of proteins mediating the DNA-damage response. The Ku70/80 heterodimer is the regulatory subunit of the DNA-dependent protein kinase (DNA-PK) and its DNA-binding activity mediates DNA double-strand breaks repair. Although Ku80 was recently 2016-07-01 · Human Ku70/80 was added to a final concentration of 20 ng/μl. Compound L was added as solution in DMSO (final concentration DMSO in the EMSA reaction mixture was 5%). This reaction containing Ku70/80 and Compound L was then allowed to pre-incubate for 5 min at 37 °C.
In humans, Ku70/80 recognizes DNA broken ends and recruits the DNA-dependent Suppression of Ku70/80 or Lig4 leads to decreased stable transformation and enhanced homologous recombination in rice AyakoNishizawa-Yokoi1,SatokoNonaka1,2,HiroakiSaika1,Yong-IkKwon1,3,KeishiOsakabe1,4 andSeiichiToki1,3 The cells were labeled with Ku70/Ku80 Monoclonal Antibody (162) (Product # MA1-21818) at 1:100 dilution in 0.1% BSA, incubated at 4 degree Celsius overnight and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Ku70/80 nonhomologous end-joining activity is essential for resolving random DNA double-strand breaks, and the Ku70/80 protein complex has been proposed as "caretaker" of genomic stability. We studied the Ku70/80 heterodimer activity in a patient affected by multiple basal cell carcinomas with a personal history of moderate exposure to ionizing radiation. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards.
The Ku70/80 heterodimer protein possesses a ring-shaped structure with high affinity for DSBs. Since this central position, the Ku70/80 dimer is a logical target for the disruption of the entire NHEJ pathway.
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In fact, the role of Ku70/80 proteins is highly complex and integrates different aspects of DNA repair. Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa.
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title = "The nuclear DNA repair protein Ku70/80 is a tumor-associated antigen displaying rapid receptor mediated endocytosis",. abstract = "To be of therapeutic It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa subunit (XRCC6) that Ku protein — G22P1 antigen — Ku70 antigen — KU80 antigen. av K Söderlund Leifler · 2009 — binding to Ku70/80, DNA-PKcs is activated by autophosphorylation and in turn phosphorylates ligase IV that is responsible for the rejoining step. Damaged ends Andra är Rad51 som interagerar med BRCA1 och BRCA2 och DNA-PK bestående av Ku70/80 och DNA-PKcs (3).
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TOFINO/LONG BEACH, CYAZ, 49.082222, -125.7725, 80 BECCLES, EGSM, 52.435278, 1.618333, 80 CASCADE, KU70, 44.492333, -116.014778, 4742. KU70 – Kontrolluppgift – Näringsbidrag och royalty. Finns som: PDF KU80 – Kontrolluppgift – Betalning från utlandet. Finns som: PDF Dessutom identifierade Yasui och hans grupp en Ku70 / Ku80-beroende rekrytering av DNA-ändarna av Ku70 / 80-heterodimeren som rekryterar DNA-PKcs. Tel: 070-538 80 97 karin.stenzelius@skane.se behandling, men däremot en ökning av nukleärt Ku70-protein. (p = 0,01), samt av DNA-PKcs STP14 - Stämjärn 14 mm - ANANT.
Anti-PRKDC Rabbit Polyclonal Antibody Cy7® VWR
2013-05-01 · When both Ku70/80 and RECQ1 were incubated with fork duplex in the presence of ATPγS, we observed a super-shifted species that is distinct from those obtained with binding of the fork DNA with Ku70/80 or RECQ1 alone (Fig.
2013-05-01 · When both Ku70/80 and RECQ1 were incubated with fork duplex in the presence of ATPγS, we observed a super-shifted species that is distinct from those obtained with binding of the fork DNA with Ku70/80 or RECQ1 alone (Fig. 3A, lane 3), indicating that Ku70/80 and RECQ1 can together bind the fork DNA structure. Persson, Oscar et al. "Distribution, cellular localization, and therapeutic potential of the tumor-associated antigen Ku70/80 in glioblastoma multiforme.".